HIV viral load in Thai men and women with subtype E infections

J Acquir Immune Defic Syndr. 2001 Apr 1;26(4):345-7. doi: 10.1097/00126334-200104010-00009.

Abstract

The assessment of potential "breakthrough infections" in HIV vaccine trials requires knowledge of viral load in unvaccinated persons. Therefore, HIV-1 RNA was quantitated in plasma from Thai adults with subtype E infections. RNA was detectable (> or =500 copies/ml) in 93% of 255 specimens, with a mean (standard deviation) value of 4.09 (0.88) log copies/ml. The concentration of RNA was directly related to the presence of AIDS-defining illnesses, inversely related to CD4 count, and independent of gender after adjustment for CD4 count.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • AIDS Vaccines / immunology
  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / virology
  • CD4 Lymphocyte Count
  • Female
  • HIV Infections / immunology
  • HIV Infections / virology*
  • HIV-1 / classification*
  • HIV-1 / genetics
  • HIV-1 / immunology
  • HIV-1 / isolation & purification*
  • Humans
  • Male
  • RNA, Viral / analysis
  • RNA, Viral / genetics
  • Sex Characteristics
  • Thailand
  • Vaccination
  • Viral Load*

Substances

  • AIDS Vaccines
  • RNA, Viral