SRY-negative XX sex reversal in a pony: a case report

Theriogenology. 2001 Mar 15;55(5):1051-7. doi: 10.1016/s0093-691x(01)00465-4.

Abstract

A three year old pony with sexually ambiguous external genitalia was found to have a normal female karyotype (64, XX) and bilateral inguinal testes. The PCR analysis of blood samples revealed the absence of the Y chromosome sequences SRY, eTSPY and ZFY. No Y chromosome sequences were identified in DNA extracted from the gonads. The mechanism whereby XX sex reversal occurs in the absence of SRY is unknown.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • DNA-Binding Proteins / blood
  • DNA-Binding Proteins / genetics*
  • Disorders of Sex Development* / genetics
  • Disorders of Sex Development* / pathology
  • Disorders of Sex Development* / veterinary*
  • Female
  • Horses / physiology*
  • Male
  • Nuclear Proteins*
  • Orchiectomy
  • Sex-Determining Region Y Protein
  • Testis / pathology
  • Testis / surgery
  • Transcription Factors*

Substances

  • DNA-Binding Proteins
  • Nuclear Proteins
  • Sex-Determining Region Y Protein
  • Transcription Factors