Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B

Biosci Biotechnol Biochem. 2001 Mar;65(3):651-3. doi: 10.1271/bbb.65.651.

Abstract

We performed a screening program to identify telomerase inhibitors from our drug source obtained from fungus fermentations, and found that two compounds, CRM646-A and thielavin B, inhibited telomerase activity at doses of 3.2 and 32 microM, respectively. These compounds also inhibited the activity of viral reverse transcriptase at almost the same dose levels which inhibited telomerase activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Hydroxybenzoates / chemistry
  • Hydroxybenzoates / pharmacology*
  • Molecular Structure
  • Telomerase / antagonists & inhibitors*
  • Telomerase / metabolism
  • U937 Cells

Substances

  • CRM646 A
  • Enzyme Inhibitors
  • Hydroxybenzoates
  • thielavin B
  • Telomerase