Abstract
A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Motifs / physiology*
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Animals
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Blotting, Northern
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Carrier Proteins*
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Cell Compartmentation / physiology*
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Cell Line
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Chromosome Mapping
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Cloning, Molecular
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Databases, Factual
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Embryo, Mammalian
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Humans
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In Situ Hybridization
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Mice
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Molecular Sequence Data
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Multigene Family / genetics*
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Mutagenesis, Site-Directed
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Nerve Tissue Proteins*
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Organ Specificity
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Protein Binding / physiology
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Protein Structure, Tertiary / physiology
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Proteins / physiology*
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Sequence Homology, Amino Acid
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Subcellular Fractions / metabolism
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Two-Hybrid System Techniques
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Ubiquitin-Protein Ligases
Substances
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Carrier Proteins
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Nerve Tissue Proteins
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Proteins
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Trim8 protein, mouse
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Ubiquitin-Protein Ligases
Associated data
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GENBANK/AF220014
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GENBANK/AF220015
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GENBANK/AF220016
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