Abstract
Kynurenic acid, an antagonist of glutamatergic ionotropic receptors and alpha7 nicotinic cholinergic receptors failed to affect nicotine-induced convulsions in mice which may indicate that alpha7 nicotinic receptor-mediated events play no role in seizure activity produced by nicotine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Dizocilpine Maleate / pharmacology
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Excitatory Amino Acid Antagonists / pharmacology*
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Injections, Intraperitoneal
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Injections, Intraventricular
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Kynurenic Acid / pharmacology*
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Male
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Mecamylamine / pharmacology
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Mice
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Nicotine*
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Nicotinic Agonists*
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Nicotinic Antagonists / pharmacology
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
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Seizures / chemically induced
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Seizures / prevention & control*
Substances
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Excitatory Amino Acid Antagonists
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Nicotinic Agonists
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Nicotinic Antagonists
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Receptors, N-Methyl-D-Aspartate
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Mecamylamine
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Dizocilpine Maleate
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Nicotine
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Kynurenic Acid