Epigenetic analysis of kinetochore assembly on variant human centromeres

Trends Genet. 2001 May;17(5):243-7. doi: 10.1016/s0168-9525(01)02283-1.

Abstract

Human centromere formation involves the assembly of the mitotic kinetochore onto chromosomal locations that contain the interphase prekinetochore. Immunofluorescent analysis of two functionally converse human centromere variants, neocentromeres and inactive centromeres, has been used to evaluate the functional significance of over 24 CENTROMERE proteins, providing important insight into the epigenetics of centromere formation and kinetochore assembly.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Centromere / genetics*
  • Chromosomal Proteins, Non-Histone / genetics
  • Chromosomal Proteins, Non-Histone / physiology
  • Chromosome Aberrations / genetics
  • Chromosome Disorders
  • Fluorescent Antibody Technique
  • Humans
  • Kinetochores*
  • Macromolecular Substances

Substances

  • Chromosomal Proteins, Non-Histone
  • Macromolecular Substances