Increased response to visual feedback of drug-induced dyskinetic movements in advanced Parkinson's disease

Neurosci Lett. 2001 May 18;304(1-2):25-8. doi: 10.1016/s0304-3940(01)01740-2.

Abstract

To investigate the response to visual feedback of involuntary movements which have a frequency composition similar to cerebellar tremor but are not caused by cerebellar damage, we have tested six advanced Parkinson's disease (PD) patients with drug-induced dyskinetic movements using visually guided wrist tracking tasks. Tracking performance was assessed under three visual conditions: (1) both guiding target and movement cursor were displayed continuously; (2) the target display was turned off for the second half of each trial; or (3) the cursor display, but not the target, was turned off for the second half of each trial. The response to visual feedback of drug-induced dyskinetic movements at 1-5 Hz in these advanced PD patients were significantly increased than in normal controls. This suggests that increased response to visual feedback might be a common feature of low frequency involuntary movements and not directly caused by cerebellar damages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Analysis of Variance
  • Biofeedback, Psychology / physiology*
  • Cues*
  • Dyskinesia, Drug-Induced / physiopathology*
  • Dyskinesia, Drug-Induced / psychology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / physiopathology*
  • Parkinson Disease / psychology
  • Photic Stimulation / methods
  • Psychomotor Performance / physiology*