Abstract
Members of the Pbx family are involved in a diverse range of developmental processes including axial patterning and organogenesis. Pbx functions are in part mediated by the interaction of Pbx proteins with members of the Hox and Meis/Prep families. We have identified a fourth mammalian Pbx family member. Pbx4 in the mouse and PBX4 in humans are located on chromosome 8 and chromosome 19, respectively. Pbx4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophase.
MeSH terms
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Amino Acid Sequence
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Animals
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Blotting, Northern
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Chromosome Mapping
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Chromosomes, Human, Pair 19
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DNA Primers
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DNA, Complementary / metabolism
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DNA-Binding Proteins / biosynthesis*
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DNA-Binding Proteins / genetics*
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Humans
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Immunohistochemistry
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In Situ Hybridization
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In Situ Hybridization, Fluorescence
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Male
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Meiosis
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Mice
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Models, Genetic
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Molecular Sequence Data
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Protein Binding
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Reverse Transcriptase Polymerase Chain Reaction
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Sequence Homology, Amino Acid
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Spermatogenesis*
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Testis / metabolism
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Tissue Distribution
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Transcription Factors
Substances
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DNA Primers
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DNA, Complementary
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DNA-Binding Proteins
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PBX4 protein, human
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Pbx4 protein, mouse
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Transcription Factors