Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1)

Biochim Biophys Acta. 2001 Jan 26;1517(2):327-31. doi: 10.1016/s0167-4781(00)00266-9.

Abstract

A new full-length cDNA encoding a novel protein was isolated from our human fetal brain cDNA library. The cDNA consists of 2701 bp and has a putative open reading frame encoding 131 amino acids which possesses a JAK binding site (Pro(46)-Ile-Pro(48) which is preceded by a cluster of hydrophobic residues) and is highly homologous to the leptin receptor gene-related protein (OB-RGRP). Northern blot analysis showed that this new gene is widely expressed in human tissues and radiation hybrid mapping placed the gene to human chromosome 8p21.1-8p21.2.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Binding Sites
  • Brain / metabolism
  • Carrier Proteins / chemistry
  • Carrier Proteins / genetics*
  • Carrier Proteins / metabolism
  • Chromosomes, Human, Pair 8
  • Cloning, Molecular
  • DNA, Complementary / chemistry
  • DNA, Complementary / isolation & purification
  • Evolution, Molecular
  • Gene Library
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Molecular Sequence Data
  • Open Reading Frames
  • Protein Isoforms / genetics
  • Receptors, Cell Surface*
  • Receptors, Leptin
  • Sequence Alignment
  • Sequence Homology

Substances

  • Carrier Proteins
  • DNA, Complementary
  • Intracellular Signaling Peptides and Proteins
  • LEPR protein, human
  • LEPROT protein, human
  • Protein Isoforms
  • Receptors, Cell Surface
  • Receptors, Leptin

Associated data

  • GENBANK/AF063605