Abstract
The Streptomyces coelicolor fab (fatty acid biosynthesis) gene cluster (fabD-fabH-acpP-fabF) is cotranscribed to produce a leaderless mRNA transcript. One of these genes, fabH, encodes a ketoacyl synthase III that is essential to and is proposed to be responsible for initiation of fatty acid biosynthesis in S. coelicolor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3-Oxoacyl-(Acyl-Carrier-Protein) Synthase / genetics*
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3-Oxoacyl-(Acyl-Carrier-Protein) Synthase / metabolism*
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Culture Media
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Fatty Acids / biosynthesis*
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Fatty Acids / genetics
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Gene Deletion
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Genes, Bacterial
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Genes, Essential*
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Multigene Family
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Streptomyces / enzymology*
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Streptomyces / genetics
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Streptomyces / growth & development
Substances
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Culture Media
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Fatty Acids
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3-ketoacyl-acyl carrier protein synthase III
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3-Oxoacyl-(Acyl-Carrier-Protein) Synthase