Specific kappa opioid receptor agonists

Farmaco. 2001 Jan-Feb;56(1-2):121-5. doi: 10.1016/s0014-827x(01)01022-9.

Abstract

The results of studies on the design of a heterocyclic scaffold for the dynorphin A pharmacophore and on structure-affinity relationships in the MPCB/CCB series are described. The representative ligands provide insights to binding modes of benzomorphan derivatives to the kappa opioid receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics, Opioid / pharmacology*
  • Animals
  • Drug Design
  • Dynorphins / pharmacology
  • Humans
  • Receptors, Opioid, kappa / agonists*
  • Structure-Activity Relationship

Substances

  • Analgesics, Opioid
  • Receptors, Opioid, kappa
  • Dynorphins