Abstract
Myoblast fusion is essential to skeletal muscle development and repair. We have demonstrated previously that human myoblasts hyperpolarize, before fusion, through the sequential expression of two K+ channels: an ether-à-go-go and an inward rectifier. This hyperpolarization is a prerequisite for fusion, as it sets the resting membrane potential in a range at which Ca2+ can enter myoblasts and thereby trigger fusion via a window current through alpha1H T channels.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antisense Elements (Genetics)
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Child
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Child, Preschool
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Humans
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In Vitro Techniques
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Infant
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Membrane Fusion / physiology
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Membrane Potentials / physiology
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Muscle Fibers, Skeletal / cytology*
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Muscle, Skeletal / cytology*
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Muscle, Skeletal / physiology
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Patch-Clamp Techniques
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Potassium / metabolism
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Potassium Channels / genetics*
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Potassium Channels / metabolism*
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Potassium Channels, Inwardly Rectifying*
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Ribonucleases
Substances
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Antisense Elements (Genetics)
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Potassium Channels
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Potassium Channels, Inwardly Rectifying
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Ribonucleases
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Potassium