Mechanisms of macrolide resistance in clinical group B streptococci isolated in France

F Fitoussi; C Loukil; I Gros; O Clermont; P Mariani; S Bonacorsi; I Le Thomas; D Deforche; E Bingen

doi:10.1128/AAC.45.6.1889-1891.2001

Mechanisms of macrolide resistance in clinical group B streptococci isolated in France

Antimicrob Agents Chemother. 2001 Jun;45(6):1889-91. doi: 10.1128/AAC.45.6.1889-1891.2001.

Authors

F Fitoussi¹, C Loukil, I Gros, O Clermont, P Mariani, S Bonacorsi, I Le Thomas, D Deforche, E Bingen

Affiliation

¹ Service de Microbiologie, Hôpital Robert Debré, 75019 Paris, France.

Abstract

Macrolide susceptibility was investigated in clinical group B streptococci obtained from neonates or pregnant women in 2000 in France. Of 490 consecutive isolates, 18% were resistant to erythromycin. The erm(B), erm(A) subclass erm(TR), and mef(A) genes were harbored by 47, 45, and 6% of these strains, respectively. Two isolates did not harbor erm or mef genes.

MeSH terms

Anti-Bacterial Agents / pharmacology*
Drug Resistance, Microbial / genetics
Female
Humans
Infant, Newborn
Macrolides
Methyltransferases / genetics*
Microbial Sensitivity Tests
Pregnancy
Streptococcus agalactiae / drug effects*
Streptococcus agalactiae / genetics
Streptococcus agalactiae / isolation & purification

Substances

Anti-Bacterial Agents
Macrolides
Methyltransferases
rRNA (adenosine-O-2'-)methyltransferase