In vitro growth of Leishmania amazonensis promastigotes resistant to pentamidine is dependent on interactions among strains

P Agnew; P Holzmuller; Y Michalakis; D Sereno; J L Lemesre; F Renaud

doi:10.1128/AAC.45.6.1928-1929.2001

In vitro growth of Leishmania amazonensis promastigotes resistant to pentamidine is dependent on interactions among strains

Antimicrob Agents Chemother. 2001 Jun;45(6):1928-9. doi: 10.1128/AAC.45.6.1928-1929.2001.

Authors

P Agnew¹, P Holzmuller, Y Michalakis, D Sereno, J L Lemesre, F Renaud

Affiliation

¹ Centre d'Etudes sur le Polymorphisme des Microorganismes (CNRS/IRD UMR 9926), IRD, 34032 Montpellier Cedex 01, France. [email protected]

Abstract

The in vitro growth of promastigote cells of Leishmania amazonensis was found to strongly depend on interactions among strains that differed in their pentamidine resistance. In particular, the growth of resistant strains was reduced when they shared the same environment with a less-resistant strain.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiprotozoal Agents / pharmacology*
Drug Resistance, Microbial
Leishmania / drug effects*
Leishmania / growth & development
Pentamidine / pharmacology*
Species Specificity

Substances

Antiprotozoal Agents
Pentamidine