Abstract
A series of 1,4-benzodiazepines, N-1-substituted with an N-isopropyl-N-phenylacetamide moiety, was synthesized and screened for CCK-A agonist activity. In vitro agonist activity on isolated guinea pig gallbladder along with in vivo induction of satiety following intraperitoneal administration in a rat feeding assay was demonstrated.
MeSH terms
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Animals
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Appetite Depressants / chemical synthesis*
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Appetite Depressants / pharmacology*
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Benzodiazepines / chemical synthesis*
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Benzodiazepines / pharmacology*
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Gallbladder / drug effects
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Guinea Pigs
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In Vitro Techniques
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Rats
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Rats, Long-Evans
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Receptor, Cholecystokinin A
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Receptors, Cholecystokinin / agonists*
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Satiety Response / drug effects
Substances
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Appetite Depressants
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Receptor, Cholecystokinin A
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Receptors, Cholecystokinin
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Benzodiazepines