Abstract
I-152 is a prodrug of NAC and MEA with potent pro-GSH effects in human macrophages, astrocytes and lymphocytes. This molecule could be of interest in HIV infection in respect to its antioxidant and anti-HIV activities, but also in other diseases to counteract oxidative stress, that is, inflammation, cardiovascular diseases, and neurodegenerative diseases.
MeSH terms
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Acetylcysteine / analogs & derivatives
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Acetylcysteine / chemical synthesis*
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Acetylcysteine / pharmacology*
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Antioxidants / chemical synthesis*
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Antioxidants / pharmacology*
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Astrocytes / drug effects
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Astrocytes / metabolism
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CD4-Positive T-Lymphocytes / drug effects
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CD4-Positive T-Lymphocytes / metabolism
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Cell Line
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Cysteamine / analogs & derivatives
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Cysteamine / chemical synthesis*
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Cysteamine / pharmacology*
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Glutathione / metabolism*
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HIV Infections / metabolism
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Humans
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Indicators and Reagents
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Macrophages / drug effects
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Macrophages / metabolism
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Monocytes / drug effects
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Monocytes / metabolism
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Prodrugs / chemical synthesis*
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Prodrugs / pharmacology*
Substances
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Antioxidants
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I-152 compound
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Indicators and Reagents
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Prodrugs
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Cysteamine
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Glutathione
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Acetylcysteine