Ig light chain variability in DNP(494)-KLH immunised sea bass (Dicentrarchus labrax L.): evidence for intra-molecular induced suppression

Dev Comp Immunol. 2001 Jun-Jul;25(5-6):387-401. doi: 10.1016/s0145-305x(01)00002-7.

Abstract

The coding sequence of the sea bass light chain was obtained by sequential anchored PCR on a head kidney cDNA library of a DNP(494)-KLH immunised sea bass. The cDNA sequence obtained codes for a leader peptide of 21aa and a mature IgL chain of 223aa. Both the amino acid sequence comparisons and neighbour-joining trees showed that the IgL chain of sea bass obtained is of the L1/G type. To study the variability of the light chain, additional PCRs on the cDNA library and cDNA from pooled head kidneys were performed. Multiple alignment of unique sequences (N=17) could be performed without introducing gaps, and showed extremely low variability in CDR1, and no variability in CDR2 or CDR3. A possible explanation for this low variability of the IgL1 chain might be the enhanced expression of monospecific anti-DNP antibodies. The isolation and characterisation of partial genomic and cDNA IgL sequences, which showed normal variability, corroborate this explanation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens / immunology*
  • Base Sequence
  • Bass / genetics*
  • Bass / immunology
  • Blotting, Southern
  • DNA, Complementary
  • Genetic Variation*
  • Haptens / immunology*
  • Hemocyanins / immunology*
  • Humans
  • Immunoglobulin Constant Regions / classification
  • Immunoglobulin Constant Regions / genetics
  • Immunoglobulin Light Chains / classification
  • Immunoglobulin Light Chains / genetics*
  • Immunoglobulin Variable Region / classification
  • Immunoglobulin Variable Region / genetics
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Homology, Amino Acid

Substances

  • 2,4-dinitrophenyl keyhole limpet hemocyanin
  • Antigens
  • DNA, Complementary
  • Haptens
  • Immunoglobulin Constant Regions
  • Immunoglobulin Light Chains
  • Immunoglobulin Variable Region
  • Hemocyanins

Associated data

  • GENBANK/AJ400216