Modified livestock virus controls HIV infections

NIAID AIDS Agenda. 1997 Nov:8.

Abstract

AIDS: A novel approach to destroying HIV-infected cells is being investigated by researchers at Yale University. Yale scientists have converted a common livestock virus that selectively targets and then exterminates the HIV cells. The cell-to-cell infection process occurs when HIV-infected cells display gp 120 (the HIV outer coat protein), thereby flagging themselves for destruction by other immune system cells. Anthony Fauci, National Institute of Allergy and Infectious Diseases (NIAID), is encouraged by the results and states that the cell-targeted system has great potential applications for HIV, cancer, and other diseases. Nava Sarver of the NIAID Division of AIDS says the Yale research targets one of the major problems in targeted delivery of genes to specific cells for treatment and disease prevention. This will eliminate the need to remove cells from the body, modify them, and then return them to the body.

Publication types

  • Newspaper Article

MeSH terms

  • Animals
  • CD4 Antigens / genetics
  • GTP-Binding Proteins / genetics
  • Gene Deletion
  • Gene Expression Regulation, Viral / physiology
  • HIV Infections / therapy*
  • HIV Infections / virology
  • HIV-1 / growth & development
  • HIV-1 / physiology*
  • Receptors, HIV / genetics
  • Vesicular stomatitis Indiana virus / physiology*
  • Viral Envelope Proteins / genetics

Substances

  • CD4 Antigens
  • Receptors, HIV
  • Viral Envelope Proteins
  • GTP-Binding Proteins