Decreased susceptibility of Th1 cells to infection with primary HIV-1 isolates is associated with lower expression of CXCR4 in these cells

P P Jagodzinski; W H Trzeciak

Decreased susceptibility of Th1 cells to infection with primary HIV-1 isolates is associated with lower expression of CXCR4 in these cells

Folia Histochem Cytobiol. 2001;39(2):123-4.

Authors

P P Jagodzinski¹, W H Trzeciak

Affiliation

¹ Department of Biochemistry and Molecular Biology, University of Medical Sciences, Poznan, Poland. [email protected]

PMID: 11374787

Abstract

The HIV-1 X4-isolates replicate more efficiently in Th2 than in Th1 cells, isolated from peripheral blood lymphocytes of HIV-1 seronegative individuals. The semiquantitative RT-PCR revealed higher level of transcripts of the HIV-1 co-receptor CXCR4 in Th2 cells than in Th1 cells which might explain better replication of HIV-1 X4-isolates in these cells. Lower expression of CXCR4 in Th1 cells render these cells less susceptible to infection with HIV-1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Separation
Clone Cells
HIV Infections / genetics
HIV Infections / metabolism*
HIV Infections / virology*
HIV-1*
Humans
In Vitro Techniques
RNA, Viral / biosynthesis
Receptors, CXCR4 / biosynthesis*
Receptors, CXCR4 / genetics
Reverse Transcriptase Polymerase Chain Reaction
Th1 Cells / metabolism*
Th1 Cells / virology*
Th2 Cells / metabolism
Th2 Cells / virology

Substances

RNA, Viral
Receptors, CXCR4