New approach in drug development: whole blood pharmacodynamic assays reflect biological activities of tacrolimus

Transplant Proc. 2001 May;33(3):2172. doi: 10.1016/s0041-1345(01)01930-3.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Differentiation, T-Lymphocyte / analysis
  • Cells, Cultured
  • Drug Design
  • Immunosuppressive Agents / blood
  • Immunosuppressive Agents / pharmacokinetics
  • Immunosuppressive Agents / pharmacology
  • Lymphocyte Activation / drug effects*
  • Lymphocytes / drug effects
  • Lymphocytes / immunology*
  • Macaca fascicularis
  • T-Lymphocyte Subsets / drug effects
  • T-Lymphocyte Subsets / immunology*
  • Tacrolimus / blood*
  • Tacrolimus / pharmacokinetics
  • Tacrolimus / pharmacology*

Substances

  • Antigens, Differentiation, T-Lymphocyte
  • Immunosuppressive Agents
  • Tacrolimus