Lack of p53 accelerates hepatocarcinogenesis in transgenic mice constitutively overexpressing c-myc in the liver

FASEB J. 2001 Jun;15(8):1404-6. doi: 10.1096/fj.00-0487fje.

Authors

R Klocke¹, T Bartels, G Jennings, K Brand, R Halter, M Strauss, D Paul

Affiliation

¹ Fraunhofer Institute of Toxicology and Aerosol Research, Department of Cell Biology, D-30625 Hannover, Germany. [email protected]

PMID: 11387238
DOI: 10.1096/fj.00-0487fje

No abstract available

MeSH terms

Animals
Carcinoma, Hepatocellular / etiology*
Carcinoma, Hepatocellular / mortality
Cell Transformation, Neoplastic
Genetic Predisposition to Disease
Liver / metabolism
Liver Neoplasms / etiology*
Liver Neoplasms / mortality
Mice
Mice, Transgenic
Models, Biological
Proto-Oncogene Proteins c-myc / biosynthesis*
Proto-Oncogene Proteins c-myc / genetics
Survival Analysis
Tumor Suppressor Protein p53 / deficiency*
Tumor Suppressor Protein p53 / genetics

Substances

Proto-Oncogene Proteins c-myc
Tumor Suppressor Protein p53