Abstract
The steep relationship between active force and length in cardiac muscle is based on a length dependence of myofilament Ca(2+) sensitivity. However, it is not muscle length but the lateral spacing between actin and myosin filaments that sets the level of Ca(2+) sensitivity, mainly through modulation of myosin-mediated activation of the thin filament.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Actin Cytoskeleton / metabolism*
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Animals
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Calcium / metabolism*
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Cross-Linking Reagents / metabolism*
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Muscle Fibers, Skeletal / metabolism*
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Muscle, Skeletal / cytology
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Muscle, Skeletal / metabolism
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Myocardium / cytology
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Myocardium / metabolism
Substances
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Cross-Linking Reagents
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Calcium