Abstract
Bioassay-directed fractionation of the stems of Rollinia mucosa led to the isolation of new N-methoxycarbonyl aporphine alkaloids, romucosine A (1), romucosine B (2), romucosine C (3), and romucosine D (4), along with the known alkaloid, N-methoxylcarbonyl-nornuciferine (5). Alkaloids 1 and 4 exhibited significant inhibition of collagen, arachidonic acid, and platelet activating factor-induced platelet aggregation, and alkaloid 3 also showed an inhibitory effect on arachidonic acid induced platelet aggregation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Aporphines / chemistry*
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Aporphines / isolation & purification
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Aporphines / pharmacology*
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Humans
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Magnetic Resonance Spectroscopy
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Magnoliopsida / chemistry*
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Models, Molecular
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Molecular Conformation
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Molecular Structure
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / chemistry
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Platelet Aggregation Inhibitors / isolation & purification
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Platelet Aggregation Inhibitors / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
Substances
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Alkaloids
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Aporphines
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Platelet Aggregation Inhibitors