Abstract
In a series of 185 patients (median age 7 years) of acute lymphoblastic leukaemia (ALL) from India, the overall incidence of ALL-1 gene rearrangement using the Southern blot technique was 11.4% (21/185). The incidence amongst the infants (age < or = 1 year, 70%) was significantly higher when compared to patients > 1 - < or = 10 years (7.4%, P = 0.00001) as well as > 10 years old (9.3%, P = 0.0001). ALL-1 gene rearrangement was associated with significantly higher WBC count (P = 0.01) and CD10 negativity (P = 0.00000001). Complete remission (CR) and relapse rates in 98 patients evaluable for response to therapy on a uniform therapy protocol was independent of ALL-1 gene status.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
-
Child
-
Child, Preschool
-
DNA-Binding Proteins / genetics*
-
Female
-
Gene Rearrangement
-
Histone-Lysine N-Methyltransferase
-
Humans
-
Incidence
-
India / epidemiology
-
Infant
-
Male
-
Myeloid-Lymphoid Leukemia Protein
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
-
Proto-Oncogenes*
-
Transcription Factors*
-
Treatment Outcome
Substances
-
DNA-Binding Proteins
-
KMT2A protein, human
-
Transcription Factors
-
Myeloid-Lymphoid Leukemia Protein
-
Histone-Lysine N-Methyltransferase