Abstract
Hematopoietic neoplasms developing in AKXD recombinant inbred, NFS.V(+) and ICSBP knockout mice were assessed using morphologic, cytologic and molecular criteria that relate these disorders to human lymphoma and leukemia. Lymphoma types included precursor T-cell and B-cell lymphoblastic, small lymphocytic, splenic marginal zone, follicular, and diffuse large cell (DLCL). In addition to previously defined subtypes of DLCL composed of centroblasts or immunoblasts, two additional subtypes are defined here: lymphoblastic lymphoma like (LL) and lymphoma characterized by a histiocytic reaction (HS). DLCL(HS) were distinguished from true histiocytic lymphomas by the presence of clonal Ig gene rearrangements.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Crosses, Genetic
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Disease Models, Animal
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Female
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Gene Rearrangement
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Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / genetics
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Genes, T-Cell Receptor beta / genetics
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Immunoglobulin Heavy Chains / genetics
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Immunoglobulin kappa-Chains / genetics
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Lymphoma, Large B-Cell, Diffuse / classification
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Lymphoma, Large B-Cell, Diffuse / genetics
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Lymphoma, Large B-Cell, Diffuse / pathology
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Lymphoma, Non-Hodgkin / classification
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Lymphoma, Non-Hodgkin / genetics
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Lymphoma, Non-Hodgkin / pathology*
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Mice
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Mice, Inbred AKR
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Mice, Inbred DBA
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Mice, Knockout
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / classification
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
Substances
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Immunoglobulin Heavy Chains
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Immunoglobulin kappa-Chains