Clinical protocol. An open-label, phase I, dose-escalation study of tumor necrosis factor-alpha (TNFerade Biologic) gene transfer with radiation therapy for locally advanced, recurrent, or metastatic solid tumors

MeSH terms

• Adverse Drug Reaction Reporting Systems / standards
• Clinical Protocols* / standards
• Clinical Trials, Phase I as Topic* / legislation & jurisprudence
• Clinical Trials, Phase I as Topic* / methods
• Clinical Trials, Phase I as Topic* / standards
• Combined Modality Therapy
• Drug Administration Schedule
• Female
• Gene Transfer Techniques
• Humans
• Male
• Neoplasm Metastasis / drug therapy*
• Neoplasm Metastasis / radiotherapy*
• Neoplasms / drug therapy*
• Neoplasms / radiotherapy*
• Patient Selection
• Tumor Necrosis Factor-alpha / administration & dosage*
• Tumor Necrosis Factor-alpha / adverse effects
• Tumor Necrosis Factor-alpha / genetics
• Tumor Necrosis Factor-alpha / therapeutic use*