Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss

R Cabal-Manzano; P Bhargava; A Torres-Duarte; J Marshall; P Bhargava; I W Wainer

doi:10.1054/bjoc.2001.1830

Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss

Br J Cancer. 2001 Jun 15;84(12):1599-601. doi: 10.1054/bjoc.2001.1830.

Authors

R Cabal-Manzano¹, P Bhargava, A Torres-Duarte, J Marshall, P Bhargava, I W Wainer

Affiliation

¹ Lombardi Cancer Center, Georgetown University Medical Center, 3800 Reservoir Road NW, Washington DC 20007, USA.

Abstract

Proteolysis-inducing factor (PIF), a novel cachectic factor, is detectable in the urine of cancer patients experiencing weight loss. We report the expression of PIF in gastrointestinal cancers, and a correlation between PIF expression in tumours, its detection in urine and weight-loss. These data provide the first direct evidence that tumours are the source of PIF in humans.

MeSH terms

Animals
Appetite
Blood Proteins / biosynthesis*
Blood Proteins / urine
Cachexia / etiology*
Cachexia / physiopathology
Disease Models, Animal
Gastrointestinal Neoplasms / complications*
Gastrointestinal Neoplasms / physiopathology
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Mice
Proteoglycans
Weight Loss*

Substances

Blood Proteins
Proteoglycans
proteolysis-inducing peptide