Hyphae and yeasts of Candida albicans differentially regulate interleukin-12 production by human blood monocytes: inhibitory role of C. albicans germination

Infect Immun. 2001 Jul;69(7):4695-7. doi: 10.1128/IAI.69.7.4695-4697.2001.

Abstract

The role of Candida albicans yeast-to-hyphae transition in interleukin-12 (IL-12) production by monocytes was investigated. Germinating C. albicans not only failed to induce IL-12 p70 but also suppressed IL-12 production induced by heat-killed C. albicans. Comparison of the abilities of germinating C. albicans and agerminating mutants to inhibit IL-12 production showed that germination of C. albicans plays a critical role in the inhibition of IL-12 production.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Candida albicans / immunology*
  • Candida albicans / isolation & purification
  • Candida albicans / physiology
  • Cells, Cultured
  • Humans
  • Interleukin-12 / biosynthesis*
  • Interleukin-12 / genetics
  • Monocytes / immunology*
  • Monocytes / microbiology

Substances

  • Interleukin-12