Abstract
Recent efforts in our laboratories have resulted in a synthetic approach toward C2'-alkylated K252a analogues via extension of a K252a cyclofuranosylation strategy. The bis-indole-N-glycosidic coupling of 6-N-(3,4-dimethoxybenzyl)-staurosporinone (21) with a number of highly functionalized carbohydrates has given access to previously unattainable, biologically relevant analogues.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alkylation
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Carbazoles / chemical synthesis*
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Enzyme Inhibitors / chemical synthesis*
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Indicators and Reagents
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Indole Alkaloids
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Molecular Conformation
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Protein Kinase C / antagonists & inhibitors*
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Stereoisomerism
Substances
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Carbazoles
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Enzyme Inhibitors
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Indicators and Reagents
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Indole Alkaloids
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staurosporine aglycone
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Protein Kinase C