Tec kinases: modulators of lymphocyte signaling and development

C M Lewis; C Broussard; M J Czar; P L Schwartzberg

doi:10.1016/s0952-7915(00)00221-1

Tec kinases: modulators of lymphocyte signaling and development

Curr Opin Immunol. 2001 Jun;13(3):317-25. doi: 10.1016/s0952-7915(00)00221-1.

Authors

C M Lewis¹, C Broussard, M J Czar, P L Schwartzberg

Affiliation

¹ National Human Genome Research Institute, National Institutes of Health, 20892, Bethesda, MD, USA.

PMID: 11406363
DOI: 10.1016/s0952-7915(00)00221-1

Abstract

The Tec kinases are implicated as important components of the antigen receptor signaling required for proper lymphocyte activation and development. Recent data suggest that these kinases contribute to multiprotein complexes containing LAT and SLP-76 in T cells, and BLNK/SLP-65 in B cells, which are required for activation of PLC-gamma and downstream pathways.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Differentiation / immunology
Humans
Lymphocyte Activation / immunology
Lymphocytes / cytology*
Lymphocytes / enzymology*
Lymphocytes / immunology
Protein-Tyrosine Kinases / physiology*
Signal Transduction / immunology*

Substances

Tec protein-tyrosine kinase
Protein-Tyrosine Kinases