Effects of minor constituents (non-glyceride compounds) of virgin olive oil on plasma lipid concentrations in male Wistar rats

Clin Nutr. 2001 Jun;20(3):211-5. doi: 10.1054/clnu.2000.0382.

Abstract

We aimed to assess the effects of minor constituents (MC) from virgin olive oil upon the plasma lipid profile of experimental animals. Therefore, 32 Wistar rats were fed for 6 weeks with one of four different diets with a similar fatty acid composition but different MC: high-oleic sunflower oil (HOSO), virgin olive oil (VOO), 400%-MC enriched olive oil (EOO) and MC poor (impoverished) olive oil (IOO). At the end of the week 6 of dietary treatment, blood samples were obtained for analysis of lipid composition. A statistically significant influence was observed upon both total HDL (1.593+/-0.4, 1.204+/-0.212, 0.991+/-0.244 and 0.827+/-0.279 mmol/L for EOO, HOSO, VOO and IOO, respectively, Kruskal-Wallis test, P<0.05) and HDL(2)cholesterol levels (1.16+/-0.26, 0.576+/-0.191, 0.585+/-0.216 and 0.583+/-0.207 mmol/L for EOO, HOSO, VOO and IOO, respectively, Kruskal-Wallis test, P<0.05). No statistically significant effect was observed upon LDL-cholesterol or triglycerides. Thus, MC supplementation has beneficial effects on HDL concentrations in Wistar rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Weight
  • Cardiovascular Diseases / drug therapy
  • Cardiovascular Diseases / prevention & control*
  • Fatty Acids, Monounsaturated / administration & dosage*
  • Lipids / blood*
  • Lipoproteins, HDL / blood
  • Lipoproteins, HDL / drug effects*
  • Male
  • Olive Oil
  • Phenols / administration & dosage
  • Plant Oils / administration & dosage*
  • Plant Oils / chemistry
  • Rats
  • Rats, Wistar
  • Sunflower Oil

Substances

  • Fatty Acids, Monounsaturated
  • Lipids
  • Lipoproteins, HDL
  • Olive Oil
  • Phenols
  • Plant Oils
  • Sunflower Oil