Comparative in vitro activity of ABT-773, a novel antibacterial ketolide

A M Nilius; M H Bui; L Almer; D Hensey-Rudloff; J Beyer; Z Ma; Y S Or; R K Flamm

doi:10.1128/AAC.45.7.2163-2168.2001

Comparative in vitro activity of ABT-773, a novel antibacterial ketolide

Antimicrob Agents Chemother. 2001 Jul;45(7):2163-8. doi: 10.1128/AAC.45.7.2163-2168.2001.

Authors

A M Nilius¹, M H Bui, L Almer, D Hensey-Rudloff, J Beyer, Z Ma, Y S Or, R K Flamm

Affiliation

¹ Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537, USA. [email protected]

Abstract

The in vitro activities of ABT-773, erythromycin, clarithromycin, and azithromycin were compared. ABT-773 was the most active compound against macrolide-susceptible Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Enterococcus spp. and multidrug-resistant Streptococcus pneumoniae. It also had good activity against gram-negative and atypical respiratory tract pathogens and Helicobacter pylori.

Publication types

Comparative Study

MeSH terms

Anti-Bacterial Agents / pharmacology*
Azithromycin / pharmacology
Clarithromycin / pharmacology
Drug Resistance, Multiple
Enterococcus / drug effects
Erythromycin / analogs & derivatives*
Erythromycin / pharmacology*
Helicobacter pylori / drug effects
Humans
Ketolides*
Microbial Sensitivity Tests
Staphylococcus / drug effects
Streptococcus / drug effects
Time Factors

Substances

Anti-Bacterial Agents
Ketolides
Erythromycin
Azithromycin
Clarithromycin
cethromycin