Evaluation of rapid immunocapture assays for diagnosis of Plasmodium vivax in Korea

Parasitol Res. 2001 Jun;87(6):445-8. doi: 10.1007/s004360000360.

Abstract

The rapid immunocapture assays, OptiMal and ICT, were evaluated from 87 individuals for the diagnosis of malaria infections directly from whole blood. A total of 87 individuals was examined for malaria parasites by microscopic examination of Giemsa-stained blood smears, and 65 cases were positive for Plasmodium vivax by microscopy. Correspondingly, the OptiMal test identified malaria infection in 45 cases (69.2%) of microscopy positive cases. Of these, two cases were misinterpreted as Plasmodium falciparum, whereas ICT detected P. vivax infection in 29 (44.6%) patients. We would like to propose that rapid immuno capture assays are an easy method that can serve as a useful tool in addition to microscopy for the diagnosis of malaria, but sensitivity is not yet satisfactory for diagnosis of P. vivax in Korea.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA Primers / chemistry
  • DNA, Protozoan / analysis
  • Humans
  • Immunoassay / standards*
  • Korea / epidemiology
  • Malaria, Vivax / blood
  • Malaria, Vivax / diagnosis*
  • Malaria, Vivax / epidemiology
  • Parasitemia / diagnosis
  • Plasmodium vivax / immunology*
  • Polymerase Chain Reaction
  • Predictive Value of Tests
  • Reagent Kits, Diagnostic / standards
  • Sensitivity and Specificity

Substances

  • DNA Primers
  • DNA, Protozoan
  • Reagent Kits, Diagnostic