Asymmetric synthesis of the tricyclic core of NGF-inducing cyathane diterpenes via a transition-metal-catalyzed [5 + 2] cycloaddition

Org Lett. 2001 Jun 28;3(13):2105-8. doi: 10.1021/ol0160699.

Abstract

[reaction: see text] A concise asymmetric synthesis of the tricyclic core of cyathane diterpenes is described, based on a novel transition-metal-catalyzed intramolecular [5 + 2] cycloaddition of ynone-vinylcyclopropane 10 (assembled from commercially available (S)-(-)-limonene), which proceeds in 90% yield with >95% selectivity. This strategy provides efficient access (14 steps and 13% overall yield) to potential analogues as well as precursors of nerve growth factor (NGF)-inducing diterpenes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cyclohexenes
  • Diterpenes / chemical synthesis*
  • Diterpenes / chemistry
  • Diterpenes / pharmacology
  • Limonene
  • Nerve Growth Factor / drug effects
  • Nerve Growth Factor / metabolism
  • Terpenes / chemistry

Substances

  • Cyclohexenes
  • Diterpenes
  • Terpenes
  • allocyathin B2
  • scabronine E
  • Nerve Growth Factor
  • Limonene