Synthesis and biological activity of glycosyl conjugates of N-(4-hydroxyphenyl)retinamide

J Y Winum; A Leydet; M Seman; J L Montero

doi:10.1016/s0014-827x(01)01074-6

Synthesis and biological activity of glycosyl conjugates of N-(4-hydroxyphenyl)retinamide

Farmaco. 2001 Apr;56(4):319-24. doi: 10.1016/s0014-827x(01)01074-6.

Authors

J Y Winum¹, A Leydet, M Seman, J L Montero

Affiliation

¹ Laboratoire de Chimie Biomoléculaire, Synthèse et Développement de Composes d'Intérêt Biologique, UMR 5032, Université Montpellier II-CNRS-Mayoly Spindler, France.

PMID: 11421261
DOI: 10.1016/s0014-827x(01)01074-6

Abstract

Three glycosyl (glucosyl, galactosyl, mannosyl) conjugates of 4-hydroxyphenylretinamide have been synthesized and tested on a broad variety of tumor cells. All three compounds are active on promyelocytic leukemia cell lines HL60 but less than the parent compound 4-HPR. Among them, the mannosyl analog stands out by its very low toxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology*
Drug Screening Assays, Antitumor
Fibroblasts / drug effects
HL-60 Cells
Humans
Indicators and Reagents
Magnetic Resonance Spectroscopy
Monocytes / drug effects
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Indicators and Reagents