A circadian system model with feedback of cross-correlation between sleep-wake rhythm and oscillator

Psychiatry Clin Neurosci. 2001 Jun;55(3):295-7. doi: 10.1046/j.1440-1819.2001.00865.x.

Abstract

Recent findings suggest that social entrainment factors work on an oscillator other than the temperature and melatonin rhythms. This indicates that there is a feedback loop affected on oscillators. In the present study, a circadian system model, including mutually coupled two oscillators and sleep-wake rhythm, is constructed, where cross-correlation between a sleep-wake rhythm and an oscillator is set to modify the coupling from one oscillator to the other. Based on the model simulation, a mechanism underlying delayed sleep phase syndrome is elucidated by the reduction in the cross-correlation resulting from dissociation between the delayed sleep phase and the oscillator.

MeSH terms

  • Body Temperature / physiology
  • Circadian Rhythm / physiology*
  • Feedback / physiology*
  • Humans
  • Light*
  • Melatonin / physiology
  • Models, Biological*
  • Wakefulness / physiology*

Substances

  • Melatonin