Hepatitis delta virus genotypes I and III circulate associated with hepatitis B virus genotype F In Venezuela

J Med Virol. 2001 Jul;64(3):356-9. doi: 10.1002/jmv.1058.

Abstract

The genotypes of hepatitis B (HBV) and delta (HDV) viruses circulating among Venezuelan Amerindian populations, where these viruses are endemic, were determined by sequencing of PCR amplified products from HBsAg positive sera. HDV genotype I (n = 7, 6 from West Amerindians), and III (n = 5, 4 from South Amerindians), were found. Only one HDV genotype I isolate was associated with HBV genotype D, 4 HDV genotype I and 2 HDV genotype III infected individuals were co-infected with HBV genotype F. The failure to detect the South American HDV genotype III in West Amerindians might be related to the outbreak of fulminant hepatitis with high mortality rate occurred between 1979 and 1982, probably affecting more the Amerindians infected with HDV genotype III. These results suggest the circulation of HDV genotype I among Amerindians, probably introduced through European immigrations, and that this HDV genotype is able to replicate in association with HBV genotype F.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Biomarkers / analysis*
  • Biomarkers / blood
  • DNA, Viral / analysis*
  • DNA, Viral / blood
  • Genotype
  • Hepatitis Antibodies / analysis*
  • Hepatitis Antibodies / blood
  • Hepatitis Antibodies / immunology
  • Hepatitis B / blood
  • Hepatitis B / virology
  • Hepatitis B Surface Antigens / analysis
  • Hepatitis B Surface Antigens / blood
  • Hepatitis B virus / genetics*
  • Hepatitis B virus / isolation & purification
  • Hepatitis D / blood
  • Hepatitis D / complications*
  • Hepatitis D / epidemiology
  • Hepatitis D / genetics*
  • Hepatitis D / virology
  • Hepatitis D, Chronic / blood
  • Hepatitis D, Chronic / complications*
  • Hepatitis D, Chronic / epidemiology
  • Hepatitis D, Chronic / virology
  • Hepatitis Delta Virus / genetics*
  • Hepatitis Delta Virus / isolation & purification
  • Humans
  • Indians, South American / classification
  • Indians, South American / genetics*
  • Phylogeny
  • Polymerase Chain Reaction
  • RNA, Viral / analysis*
  • RNA, Viral / blood
  • Sequence Alignment
  • Venezuela / epidemiology

Substances

  • Biomarkers
  • DNA, Viral
  • Hepatitis Antibodies
  • Hepatitis B Surface Antigens
  • RNA, Viral