Abstract
Amyloid formation plays a central role in the cause and progression of Alzheimer's disease. The major component of this amyloid is the amyloid-beta (A beta) peptide, which is currently the subject of intense study. This review discusses some recent studies in the area of A beta synthesis, purification and structural analysis. Also discussed are proposed mechanisms for A beta-induced neurotoxicity and some recent advances in the development of A beta-related therapeutic strategies.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alzheimer Disease / metabolism*
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Amino Acid Sequence
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Amyloid beta-Peptides / chemistry*
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Amyloid beta-Peptides / physiology*
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Animals
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Circular Dichroism
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Humans
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Magnetic Resonance Spectroscopy
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Models, Biological
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Models, Chemical
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Molecular Sequence Data
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Peptides / chemistry*
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Peptides / physiology*
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Protein Binding
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Protein Isoforms
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Protein Structure, Secondary
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Protein Structure, Tertiary
Substances
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Amyloid beta-Peptides
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Peptides
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Protein Isoforms