Translational control by CPEB: a means to the end

Nat Rev Mol Cell Biol. 2001 Jul;2(7):521-9. doi: 10.1038/35080081.

Abstract

The regulated translation of messenger RNA is essential for cell-cycle progression, establishment of the body plan during early development, and modulation of key activities in the central nervous system. Cytoplasmic polyadenylation, which is one mechanism of controlling translation, is driven by CPEB--a highly conserved, sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element, and modulates translational repression and mRNA localization. What are the features and functions of this multifaceted protein?

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology
  • Cytoplasm / metabolism
  • Gene Expression Regulation
  • Humans
  • Models, Biological
  • Molecular Structure
  • Neuronal Plasticity
  • Oocytes / physiology
  • Phylogeny
  • Protein Biosynthesis*
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*
  • Transcription Factors / chemistry
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Xenopus Proteins*
  • Xenopus laevis / embryology
  • mRNA Cleavage and Polyadenylation Factors*

Substances

  • CPEB1 protein, human
  • Cpeb1 protein, Xenopus
  • RNA, Messenger
  • RNA-Binding Proteins
  • Transcription Factors
  • Xenopus Proteins
  • mRNA Cleavage and Polyadenylation Factors