Genomic organization and refined mapping of the human nuclear corepressor 2 (NCOR2)/ silencing mediator of retinoid and thyroid hormone receptor (SMRT) gene on chromosome 12q24.3

Cytogenet Cell Genet. 2001;92(3-4):217-20. doi: 10.1159/000056906.

Abstract

The human nuclear co-repressor 2 (N-CoR2) gene (NCOR2, previously called silencing mediator for retinoid and thyroid hormone receptor SMRT) is recruited to nuclear and non-nuclear receptors in a large repressing complex containing also N-CoR1, mSin3 and HDACs. This large complex represses transcription in absence of ligand. Herein we report the high- resolution and refined mapping of NCOR2 at the boundary of sub-bands 12q24.23 and 12q24.31, and its intron/exon structure. The gene contains 45 exons. This information should allow further study of potential NCOR2 genomic alteration in some subsets of malignancies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Banding
  • Chromosomes, Human, Pair 12 / genetics*
  • Cloning, Molecular
  • DNA-Binding Proteins / genetics*
  • Exons / genetics*
  • Humans
  • In Situ Hybridization, Fluorescence*
  • Introns / genetics*
  • Nuclear Receptor Co-Repressor 2
  • Physical Chromosome Mapping
  • Repressor Proteins / genetics*

Substances

  • DNA-Binding Proteins
  • NCOR2 protein, human
  • Nuclear Receptor Co-Repressor 2
  • Repressor Proteins