Synthesis and properties of 7-hydroxyalkyl-8-benzylaminotheophyllines

Pol J Pharmacol Pharm. 1975 May-Jun;27(3):305-9.

Abstract

The synthetic routes leading to 7-beta-hydroxyethyl- (I) and 7-beta-hydroxypropyl-8-benzylaminotheophylline (II) were described. Particularly the opening of oxazolidine ring in easy available oxazolidine-(2,3-f)-theophyllines with benzylamine was investigated. The structure of I, II and acetyl derivatives Ia, Ib, IIa and IIb was also confirmed by UV spectra.

MeSH terms

  • Animals
  • Lethal Dose 50
  • Mice
  • Spectrophotometry, Ultraviolet
  • Theophylline / analogs & derivatives*
  • Theophylline / chemical synthesis
  • Theophylline / toxicity

Substances

  • Theophylline