Development and application of a carbonyl-(13)C-enriched backbone amide linker for solid-phase reaction monitoring

C Jamieson; M S Congreve; P R Hewitt; J J Scicinski; S V Ley

doi:10.1021/cc010012w

Development and application of a carbonyl-(13)C-enriched backbone amide linker for solid-phase reaction monitoring

J Comb Chem. 2001 Jul-Aug;3(4):397-9. doi: 10.1021/cc010012w.

Authors

C Jamieson¹, M S Congreve, P R Hewitt, J J Scicinski, S V Ley

Affiliation

¹ Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

PMID: 11442397
DOI: 10.1021/cc010012w

Abstract

The synthesis and application of a carbonyl-(13)C backbone amide linker are described. The labeled unit is conveniently mixed with commercial resins, providing a rapid means of monitoring chemistry performed with this linker on solid support using conventional (13)C NMR methods.