This paper examines the associations among stressful life events, social support, and depressive symptoms in a sample of 580 first-time welfare recipients. Self-reported number of depressive symptoms was greater than in corresponding community samples. Stressors and social supports made independent main effect contributions to depressive symptoms in a multiple regression analysis. Women with transportation barriers to employment, those experiencing greater numbers of stressful life events, and those who were less satisfied with their housing situation reported greater numbers of depressive symptoms. In contrast, women who were more satisfied with their social support and those with higher attendance at religious services reported fewer depressive symptoms. Implications for welfare reform policy and programs are discussed.