Large-scale chromatin decondensation and recondensation regulated by transcription from a natural promoter

J Cell Biol. 2001 Jul 9;154(1):33-48. doi: 10.1083/jcb.200011069.

Abstract

We have examined the relationship between transcription and chromatin structure using a tandem array of the mouse mammary tumor virus (MMTV) promoter driving a ras reporter. The array was visualized as a distinctive fluorescent structure in live cells stably transformed with a green fluorescent protein (GFP)-tagged glucocorticoid receptor (GR), which localizes to the repeated MMTV elements after steroid hormone treatment. Also found at the array by immunofluorescence were two different steroid receptor coactivators (SRC1 and CBP) with acetyltransferase activity, a chromatin remodeler (BRG1), and two transcription factors (NFI and AP-2). Within 3 h after hormone addition, arrays visualized by GFP-GR or DNA fluorescent in situ hybridization (FISH) decondensed to varying degrees, in the most pronounced cases from a approximately 0.5-microm spot to form a fiber 1-10 microm long. Arrays later recondensed by 3-8 h of hormone treatment. The degree of decondensation was proportional to the amount of transcript produced by the array as detected by RNA FISH. Decondensation was blocked by two different drugs that inhibit polymerase II, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) and alpha-amanitin. These observations demonstrate a role for polymerase in producing and maintaining decondensed chromatin. They also support fiber-packing models of higher order structure and suggest that transcription from a natural promoter may occur at much higher DNA-packing densities than reported previously.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amanitins / pharmacology
  • Animals
  • Carrier Proteins / metabolism
  • Chromatin / chemistry*
  • Chromatin / metabolism*
  • Chromatin / ultrastructure
  • DNA / metabolism
  • DNA Helicases
  • DNA-Binding Proteins / metabolism
  • Dichlororibofuranosylbenzimidazole / pharmacology
  • Enzyme Inhibitors / pharmacology
  • Genes, ras / genetics
  • Green Fluorescent Proteins
  • Histone Acetyltransferases
  • In Situ Hybridization, Fluorescence
  • Luminescent Proteins / metabolism
  • Mammary Tumor Virus, Mouse / genetics
  • Mice
  • Microscopy, Fluorescence
  • NFI Transcription Factors
  • Nuclear Proteins / metabolism
  • Nuclear Receptor Coactivator 1
  • Promoter Regions, Genetic*
  • Receptors, Glucocorticoid / metabolism
  • Recombinant Fusion Proteins / metabolism
  • Time Factors
  • Transcription Factor AP-2
  • Transcription Factors / metabolism
  • Transcription, Genetic*
  • Transfection

Substances

  • Amanitins
  • Carrier Proteins
  • Chromatin
  • DNA-Binding Proteins
  • Enzyme Inhibitors
  • Luminescent Proteins
  • NFI Transcription Factors
  • NFI-A2 protein, rat
  • Nuclear Proteins
  • Receptors, Glucocorticoid
  • Recombinant Fusion Proteins
  • Transcription Factor AP-2
  • Transcription Factors
  • citrate-binding transport protein
  • Green Fluorescent Proteins
  • Dichlororibofuranosylbenzimidazole
  • DNA
  • Histone Acetyltransferases
  • Ncoa1 protein, mouse
  • Nuclear Receptor Coactivator 1
  • Smarca4 protein, mouse
  • DNA Helicases