Abstract
Two new adaptor-related protein complexes, AP-3 and AP-4, have recently been identified, and both have been implicated in protein sorting at the trans-Golgi network (TGN) and/or endosomes. In addition, two families of monomeric proteins with adaptor-related domains, the GGAs and the stoned B family, have also been identified and shown to act at the TGN and plasma membrane, respectively. Together with the two conventional adaptors, AP-1 and AP-2, these proteins may act to direct different types of cargo proteins to different post-Golgi membrane compartments.
MeSH terms
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ADP-Ribosylation Factors / chemistry
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ADP-Ribosylation Factors / genetics
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ADP-Ribosylation Factors / physiology
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Adaptor Protein Complex alpha Subunits
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Adaptor Proteins, Vesicular Transport*
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Animals
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Carrier Proteins / chemistry
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Carrier Proteins / genetics
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Carrier Proteins / physiology
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Drosophila Proteins*
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Membrane Proteins / genetics
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Membrane Proteins / physiology*
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Models, Biological
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Mutation
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Nerve Tissue Proteins / physiology
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Neurons / metabolism
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Protein Structure, Tertiary
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Protein Transport
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trans-Golgi Network / metabolism
Substances
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Adaptor Protein Complex alpha Subunits
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Adaptor Proteins, Vesicular Transport
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Carrier Proteins
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Drosophila Proteins
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GGA adaptor proteins
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Membrane Proteins
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Nerve Tissue Proteins
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stnB protein, Drosophila
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ADP-Ribosylation Factors