Abstract
The discovery of Org 24598, one of the first potent and selective inhibitors of the glycine transporter is discussed. In vitro structure-activity relationships (SARs) data for interaction of a ligand with this system is discussed.
MeSH terms
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Amino Acid Transport Systems, Neutral*
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Animals
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Brain / metabolism
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Carrier Proteins / antagonists & inhibitors*
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Carrier Proteins / drug effects*
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GABA Plasma Membrane Transport Proteins
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Glycine / analogs & derivatives
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Glycine / chemical synthesis
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Glycine / pharmacology*
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Glycine Plasma Membrane Transport Proteins
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Membrane Proteins / drug effects
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Membrane Transport Proteins*
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Norepinephrine Plasma Membrane Transport Proteins
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Organic Anion Transporters*
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Radioligand Assay
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Rats
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Receptors, Glycine
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Receptors, N-Methyl-D-Aspartate / agonists*
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Sensitivity and Specificity
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Spine / metabolism
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Structure-Activity Relationship
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Symporters*
Substances
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Amino Acid Transport Systems, Neutral
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Carrier Proteins
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GABA Plasma Membrane Transport Proteins
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Glycine Plasma Membrane Transport Proteins
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Membrane Proteins
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Membrane Transport Proteins
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Norepinephrine Plasma Membrane Transport Proteins
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Organic Anion Transporters
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Receptors, Glycine
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Receptors, N-Methyl-D-Aspartate
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Slc6a2 protein, rat
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Symporters
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org 24598
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Glycine