Cloning and heterologous expression of the macrotetrolide biosynthetic gene cluster revealed a novel polyketide synthase that lacks an acyl carrier protein

J Am Chem Soc. 2001 Apr 11;123(14):3385-6. doi: 10.1021/ja0100827.

Authors

H J Kwon¹, W C Smith, L Xiang, B Shen

Affiliation

¹ Department of Chemistry, University of California One Shields Avenue, Davis, California 95616, USA.

PMID: 11457082
DOI: 10.1021/ja0100827

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Acyl Carrier Protein / chemistry
Acyl Carrier Protein / genetics*
Acyl Carrier Protein / metabolism
Alcohol Oxidoreductases / chemistry
Alcohol Oxidoreductases / genetics
Alcohol Oxidoreductases / metabolism
Anti-Bacterial Agents / biosynthesis*
Bacterial Proteins*
Base Sequence
Cloning, Molecular
DNA, Bacterial / genetics
Gene Expression
Macrolides
Molecular Sequence Data
Multienzyme Complexes / chemistry
Multienzyme Complexes / genetics*
Multienzyme Complexes / metabolism
Multigene Family*
Streptomyces griseus / enzymology
Streptomyces griseus / genetics

Substances

Acyl Carrier Protein
Anti-Bacterial Agents
Bacterial Proteins
DNA, Bacterial
Macrolides
Multienzyme Complexes
Alcohol Oxidoreductases
polyketide synthase ketoreductase

Associated data

GENBANK/AF074603
GENBANK/AF263011
GENBANK/AF263012