Abstract
A DNA methyltransferase has been identified that plays a role in maintaining the methylation status of imprinted genes. Interestingly, although expressed in the unfertilised egg, this enzyme functions only during one round of replication in the eight-cell embryo.
MeSH terms
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Animals
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DNA (Cytosine-5-)-Methyltransferase 1
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DNA (Cytosine-5-)-Methyltransferases / genetics
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DNA (Cytosine-5-)-Methyltransferases / physiology*
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DNA Methylation*
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Embryo, Mammalian / enzymology
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Female
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Genomic Imprinting*
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Mice
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Mice, Knockout
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Models, Genetic
Substances
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DNA (Cytosine-5-)-Methyltransferase 1
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DNA (Cytosine-5-)-Methyltransferases