Objective: To study the efficiency of radioimmunodetection (RID) to locate the loci of trophoblastic disease.
Method: 24 RIDs were performed with 131I labeled mouse anti-hCG monoclonal antibodies on 21 patients with trophoblastic disease.
Results: Of 24 RIDs performed, 13 were positive, including one false positive; 11 were negative, including two false negative. The sensitivity of RID was 85.7%, the specificity was 90.0%, the accuracy was 87.5%. In 8 patients who underwent operations after RID, the findings of RID were in accordance with the pathologic and immunohistologic findings.
Conclusions: RID is an efficient imaging method for trophoblastic disease. In some cases, RID showed its value as a functional diagnostic method.