Memory impairment and cholinergic dysfunction by centrally administered Abeta and carboxyl-terminal fragment of Alzheimer's APP in mice

FASEB J. 2001 Aug;15(10):1816-8. doi: 10.1096/fj.00-0859fje.

Authors

S H Choi¹, C H Park, J W Koo, J H Seo, H S Kim, S J Jeong, J H Lee, S S Kim, Y H Suh

Affiliation

¹ Department of Pharmacology, College of Medicine, National Creative Research Initiative Centre for Alzheimer's Dementia and Neuroscience Research Institute, MRC, Seoul National University, Seoul 110-799, South Korea.

PMID: 11481240
DOI: 10.1096/fj.00-0859fje

No abstract available

MeSH terms

Acetylcholine / analysis
Alzheimer Disease*
Amyloid beta-Peptides / administration & dosage*
Amyloid beta-Protein Precursor / administration & dosage*
Animals
Cerebral Cortex / chemistry
Cerebral Cortex / ultrastructure
Choline / physiology*
Cognition / drug effects
Hippocampus / chemistry
Hippocampus / ultrastructure
Injections, Intraventricular
Memory / drug effects*
Mice
Mitochondria / enzymology
Peptide Fragments / administration & dosage*
Pyruvate Dehydrogenase Complex / metabolism

Substances

Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Peptide Fragments
Pyruvate Dehydrogenase Complex
Choline
Acetylcholine